[Eruptive clear cell acanthoma].

Actas Dermosifiliogr. 2009;100:235-48 244 incidence in areas exposed to sunlight in patients with a history of basal or squamous cell carcinoma; b) other carcinogens—frequent occurrence in areas of irradiation, erythema ab igne, or following chronic exposure to arsenic; c) immunosuppression—from treatment in a liver or heart transplant setting or rheumatic diseases; and in patients with hematologic neoplasias or infection with the human immunodeficiency virus (HIV); d) cases described in patients with congenital ectodermal dysplasia or Cowden disease; and e) oncogenic viruses—although the role of Epstein-Barr virus has not been proven.8-10 In conclusion, we present a case of MCC located at a site of vaccination. As we have encountered no similar cases in the literature to date—even though the target population for anti-influenza vaccination overlaps extensively with those at greater risk of developing MCC (individuals aged 65 years or older and immunodepressed patients)—we believe this is a case of simple coincidence. However, the close temporal relationship could indicate that vaccination causes a local immune alteration through an unknown pathogenic mechanism that would facilitate the development of MCC patients with a predisposition to the disease.